Blue light-guided system to steer immune cells to the location of an infection or a developing cancer

The immune system’s ability to send its army of immune cells to the right location with the right level of response is key to the body’s ability to fight an infection or a growing tumor. An incorrect immune response, either too much or too little, can lead to cancer, autoimmune disease or inflammatory conditions, such as asthma, skin diseases and digestive disorders.

Mast cells as a sensor: Enigmatic immune cells help to avoid harmful allergens

The function of mast cells, which are part of the immune system, is still a mystery. Scientists at the German Cancer Research Center (DKFZ) have now shown that in mice mast cells function as a sensor that signals the animals to avoid antigens, including harmful allergens, which allow the mice to protect themselves from health-threatening inflammatory reactions. These findings were published in the journal Nature.