Clinical trial shows cancer-preventing topical immunotherapy trains immune system to fight precancers

A new study by investigators from Mass General Brigham uncovers how a novel immunotherapy prevents squamous cell carcinoma, with benefits lasting five years after treatment. This therapy is the first to activate specific components of the adaptive immune system, particularly CD4+ T helper cells, which are not known to be involved in traditional cancer treatments.

Discovery of ‘pliancy genes’ showcases role of latent epigenetic programs in retinal recovery 

The retina is a dynamic tissue of the eye made up of many different types of cells. Scientists at St. Jude Children’s Research Hospital used single-cell sequencing techniques to study retinal cells called Müller glia, showing that these cells have a unique set of “pliancy genes” that are open and accessible to gene expression machinery without being expressed.

Peripheral artery disease: The biggest killer you’ve probably never heard of

Imagine putting your socks on one morning and noticing your big toe, which has been painful for a few weeks, has started turning black. A trip to your doctor ends in being referred urgently to a specialist. They tell you a bypass operation of a blocked artery in your thigh is needed to save your foot. This is the reality for far too many people. In the UK, vascular surgeons performed more than 3,500 amputations in 2023.