Dressing room unrest may galvanise Bayern, says Guardiola

The row between Bayern Munich teammates Sadio Mane and Leroy Sane could actually make the German side more dangerous in the second leg of the Champions League quarterfinal on Wednesday, Manchester City manager Pep Guardiola said.

Senegal international Mane was fined and missed Saturday’s 1-1 Bundesliga draw with Hoffenheim after hitting Sane following last week’s 3-0 loss at City in the first leg.

Asked if the situation could provide a rallying point for Bayern, Guardiola told reporters: “Absolutely.

“Sometimes you need conflict to make the team more together,” added the Spaniard, who managed Bayern from 2013-16.

“It is not a weak point for them, it’s a strong point.

“I can imagine the situation against City. The best performance for Bayern Munich will be on Wednesday night.”

While City take a three-goal advantage into the second leg Guardiola said it would be dangerous to sit back.

“We have to see if we can play as we have done at home and show great courage to impose our game,” Guardiola said.

“We are able to do many, many good things and they are able to do it (too)… I want a team who is there to win the game. I know what it’s like against Bayern. If you are a little bit passive, you will suffer.” -Reuters

Targeting nurse and patient ‘supercontactors’ in health care facilities can help minimize spread of infectious diseases

New research presented at this week’s European Congress of Clinical Microbiology & Infectious Diseases (Copenhagen, April 15-18) shows how interventions focused on so-called “supercontactors” in hospitals and other long term care facilities (LTCF) can optimize infection control and reduce the spread of infectious diseases. The study is by Dr. Quentin Leclerc and colleagues at Institut Pasteur and the Conservatoire National des Arts et Métiers (Paris, France). It has been published in the journal Scientific Reports.

An early study of fecal transplant to help slow early-stage motor neuron disease progression

A randomized clinical trial is looking at whether fecal microbiota transplantation (FMT) from healthy donors into adults with early-stage amyotrophic lateral sclerosis (ALS—one of the most common forms of motor neuron disease) can modulate the immune reaction during inflammation responses that characterize disease progression, and aims to investigate the relationship between specific gut bacteria and their action on immune system cells.

Gum disease may lie at the root of some arthritis flareups

It’s a well-documented medical mystery: Patients with gum disease are less likely to respond to rheumatoid arthritis treatments. But new research may help explain this link between gum disease and an otherwise disparate condition. The findings, published in Science Translational Medicine, suggests that breaches in damaged gums allow bacteria in the mouth to seep into the bloodstream, activating an immune response that ultimately pivots to target the body’s own proteins and causes arthritis flareups.

Green Mediterranean diet promotes proximal aortic destiffening better than healthy Mediterranean diet, finds study

The green Mediterranean, high-polyphenols diet substantially regresses proximal aortic stiffness (PAS), a marker of vascular aging and increased cardiovascular risk. The green Mediterranean diet was pitted against the healthy Mediterranean diet and a healthy guideline-recommended control diet in the DIRECT PLUS, a large-scale clinical intervention trial. Researchers found that the green Mediterranean diet regressed proximal aortic stiffness by 15%, the Mediterranean diet by 7.3%, and the healthy dietary guideline-directed diet by 4.8%.

Therapeutic can seek and destroy potent opioid to treat overdoses

A new therapeutic designed by Scripps Research chemists can alter the molecular structure of the potent opioid carfentanil, inactivating the opioid and reversing a carfentanil overdose. The compound, which is described in an ACS Pharmacology & Translational Science paper published on April 17, 2023, and hasn’t yet been studied in humans, works in a fundamentally different way than existing treatments for opioid overdose.