Genome-wide CRISPR screens identify PARP inhibitor sensitivity and resistance in prostate cancer

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive. To identify previously unknown genes whose loss has a profound impact on PARP inhibitor response, researchers from Dana-Farber Brigham Cancer Center led a multinational effort to perform genome-wide CRISPR-Cas9 knockout screens. The study goal was to inform the use of PARP inhibitors beyond BRCA1/2-deficient tumors and support reevaluation of current biomarkers for PARP inhibition in prostate cancer.

Don’t let food allergies spoil your child’s fun

Children with food allergies might experience heightened anxiety over social situations involving food. They face the risk of being exposed to an allergen, or conversely, feeling excluded from normal childhood activities, such as enjoying treats at a birthday party. A Baylor College of Medicine psychologist explains how parents can alleviate this stress while teaching them to be mindful of their allergies.