Bridging the gap: Addressing medical and social needs improves diabetes care and outcomes

Nearly one in five American adults has diabetes. But that doesn’t mean the common condition is simple to treat or manage. Diabetes and its complications are the No. 1 cause of kidney failure, adult blindness, and lower-limb amputations. It’s also the seventh-leading cause of death in the U.S. As with so many chronic conditions, diabetes also disproportionately affects the most vulnerable in our communities, further exacerbating existing health disparities.

Team discovers novel anti-NET antibodies in a multinational cohort of antiphospholipid syndrome patients

Antiphospholipid syndrome is a understudied autoimmune disease that is nevertheless a leading causes of deadly blood clots and late-term pregnancy loss. An international study led by the University of Michigan researchers Ray Zuo, M.D., and Jason Knight, M.D., Ph.D., has discovered a new class of functional autoantibodies in APS patients that contributes to the disease’s development and the systemic inflammation it induces.

Lung cancer screening rates extremely low, worst among the commercially insured

A new study from the Harvey L. Neiman Health Policy Institute found that only 1.8% of eligible Americans with commercial insurance received lung cancer screening. Rates were higher but still extremely low for Original Medicare (3.4%) and Medicare Advantage (4.6%). The study, published in the Journal of the American College of Radiology, determined 2017 screening rates for patients who were eligible for lung cancer screening by low-dose computed tomography (LDCT), as determined United States Preventive Services Task Force guidelines.

Pathogenic genetic variations found to boost the risk of H. pylori–related stomach cancer

A large case-control study by international researchers at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan has found that people who carry certain genetic risk factors for gastric (stomach) cancer have a much greater risk if they have also been infected by the bacterium Helicobacter pylori. The study, published in The New England Journal of Medicine, could contribute to the development of tailored genomic medicine for treating stomach cancer.

Clinical presentation of IDDMSSD syndrome likely associated with molecular location of mutation in PAK1 gene

A recent study from Texas Children’s Hospital and Baylor College of Medicine has expanded the clinical spectrum of a new epileptic disorder called Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay (IDDMSSD) with the identification of the first recurrently affected residue identified in the protein kinase domain of PAK1 protein.