Protein isoforms could serve as novel non-small cell lung cancer biomarkers or therapeutic targets

Proteomics is the study and analysis of proteins, including their structures, functions, interactions, and modifications within a biological system. Humans have approximately 20,000 genes that produce over a million different protein variants, including an estimated 100,000 protein isoforms. These protein variants comprise the vast complexity of the proteome that has remained largely unexplored.

Imaging brain connections can predict improvements in OCD patients after deep brain stimulation

Deep brain stimulation (DBS) is a promising therapy for treatment-resistant obsessive-compulsive disorder (OCD). A first-of-its-kind collaborative study led by researchers at Texas Children’s Hospital, Baylor College of Medicine, and Brigham & Women’s Hospital has found that mapping neural connections in the brains of OCD patients offers key insights that explain the observed improvements in their clinical outcomes after DBS. The study was published in Biological Psychiatry.

Personalized gut microbiome analysis for colorectal cancer classification with explainable AI

The gut microbiome comprises a complex population of different bacterial species that are essential to human health. In recent years, scientists across several fields have found that changes in the gut microbiome can be linked to a wide variety of diseases, notably colorectal cancer (CRC). Multiple studies have revealed that a higher abundance of certain bacteria, such as Fusobacterium nucleatum and Parvimonas micra, is typically associated with CRC progression.

Opinion: AI in health care challenges us to define what better, people-centered care looks like

From faster and more accurate disease diagnosis to models of using health care resources more efficiently, AI promises a new frontier of effective and efficient health care. If it’s done right, AI may allow for more people-centered care and for clinicians to spend more time with people, doing the work they enjoy most. But to achieve these aspirations, foundational work must occur in how we operate today and in defining what health care looks like in the future.

Novel lymphoma tumor model paves way for new therapies

In recent years, innovative cancer drugs that target specific molecular drivers of the disease have been embraced as the treatment of choice for many types of cancer. But despite significant advances, there is still a lack of understanding about how the complex interactions between a tumor and its surrounding environment in the body affect cancer progression. This problem has become a well-known roadblock in making novel treatments effective for more people.