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Immune checkpoint inhibitors (ICIs) are widely sought after for the treatment of different types of cancers. Unfortunately, only 20%–30% patients with cancer respond to ICI treatment. Although the factors that influence the positive or negative response to ICI treatment are poorly understood, the strength of the ICIs’ antitumor response by TILs is thought to play a key role. Hence, investigating the antitumor response induced by ICIs might provide insights into their underlying mechanisms.

Surgical tumor removal remains one of the most common procedures during cancer treatment, with about 45% of cancer patients undergoing this surgery at some point. Thanks to recent progress in imaging and biochemical technologies, surgeons are now better able to tell tumors apart from healthy tissue. Specifically, this is enabled by a technique called “fluorescence-guided surgery” (FGS).

Children born to mothers who had COVID-19 during pregnancy may be more likely to develop obesity, according to a new study published online ahead of print in the Journal of Clinical Endocrinology & Metabolism. It is titled, “Accelerated Longitudinal Weight Gain Among Infants with In Utero COVID-19 Exposure.”

AN Immigration officer has told the Lusaka magistrate court that he was informed that Harry Findley, a Lusaka business executive crossed Mwami border in the night.
This was after one of the defense Lawyers Mr. Milner Katolo asked in cross examination if an immigration officer named Frank Michelo reviewed to the witness if he received information on Findley crossing the Mwami border.
Mr. Moses Chulu, 45, officer in charge of Mwami border testified that his colleague Mr. Michelo informed him that Findley crossed the Mwami border in the night.
In this matter, Findlay is charged with two counts of holding more than one passport and found with endorsements of forged immigration stamps.
Mr. Chulu also told the court that in September, 2022, he received an alert notice from headquarters office saying if he sees Findley trying to enter the country he should inform the security wigs or the police.
“I had called all officers from shift A and B, to ask them if Mr Findley passed that day on September 23, 2022 but all of them denied,” he submitted.
Meanwhile Ms. Selina Maziba, 28, also an Immigration officer at Mwami border told magistrate Sylvia Munyinya that Findley did not cross the border on September 23, 2022.
Ms. Maziba said Findley did not enter or exist the country on September, 23 2022 because she never saw him during her shift of duty.
“On September 23, 2022 I reported for work from 06:00hrs to 18: hours, I received an alert notice that if I see Findley crossing the border i should inform the officers in charge or the police. And on that day, he didn’t pass, I never saw him,” she said.
It is alleged, in count one, that Findlay on October 3, 2022, in Lusaka, did acquire a Zambian passport number ZP021382, purporting to have lost a Zambian passport number ZP013259, contrary to the fact.
In the second count, it is alleged that on the same date, Findlay was found in possession of endorsements of forged immigration stamps for Mwami immigration border control in his passport number ZP032178, purporting that it was officially endorsed when in fact not.
Magistrate Munyinya adjourned the matter to April 24, 2022 for continued trial.

 THE Summit for Democracy 2023 has kicked off with countries taking part echoing the importance of democracy for improved economies. The world leaders said for democracy to be revived, freedom, human rights and the rule of law should be accelerated as democracy is under threat. The leaders have also outlined disinformation distorts democracy and that […]

By NATION REPORTER
GILBERT Liswaniso has asked the Zambia Police and other law enforcement agencies to allow the more than 50 Members of Parliament to protest against the Democracy Summit which is scheduled to take place from today to tomorrow.
But Inspector General of Police Lemmy Kajoba has warned would-be protesters that the police shall not tolerate individuals planning to cause anarchy in the country.
Mr Liswaniso, the UPND national youth chairman says the police should allow the PF parliamentarians planning to protest against the Democracy Summit to go ahead but without attempts to disrupt the conference.
Mr Lwisaniso’s call to the police not to arrest the MPs is in direct conflict with the warning by Mr Jack Mwiimbu, the Minister of Home Affairs and Internal Security that those who plan protests against the Democracy Summit shall be arrested.
The UPND youth strongman said it was the democratic rights of the MPs and their constituents to remonstration against the summit but that the opposition lawmakers should know that the Summit was going to proceed regardless of their protest.
He claimed that the PF as a political organisation did not believe in democracy the reason it was willing to sabotage the summit by all means possible.
Mr Liswaniso accused the former ruling party of having adopted dictatorial tendencies while in power but that President Hakainde Hichilema had restored democracy and the police should therefore not arrest the protesters.
He said Mr. Hichilema has brought freedoms and that was why Zambia had been selected to co-host the Democracy Summit because of the country’s democratic credentials.
Zambian will co-host the Summit for Democracy on March 29 and 30 with the United States, Costa-rica Netherlands and the Republic of Korea.
Meanwhile Party for National Unity and Progress Nalolo MP, Imanga Wamunyina said in as much as the Summit for Democracy was welcome the government has not done much in giving information of what this Summit brings to the table.

By ROGERS KALERO 
MOST ministries in the UPND government are either ignorant of their core businesses, functions and responsibilities or have lost their core business functions because no one seems to know or undertand what they are doing,’ Mwenya Musenge has said
Mr Musenge, the Advocates for People’s Prosperity (APP) interim president, said one of the ministries which seem to be ignorant of its core business and responsibilities was the Ministry of Infrastructure, Housing and Urban Development which was yet to embark on any significant project from the time the new dawn administration formed government in 2021 
Mr Musenge said the ministry was receiving funding from the Central government, not only for salaries but for general government property maintenance and construction, but was yet to embark on any significant project, apart from the controversial Lusaka-Ndola dual carriage-way
“We all know that these ministries have their core businesses, functions and responsibilities. Now, interestingly, majority of these ministries have lost their core business, functions and responsibilities. Ministries like the Ministry of Infrastructure, Housing and Urban Development whose core function is to remedy government infrastructure in the country like roads, hospitals and schools.”
And Mr Musenge has challenged the Road Development Agency (RDA) to tell the nation whether it had authorised the Kitwe City Council (KCC) to use paving stones to patch up potholes on Independence Avenue

 Copperbelt Province is set to host its first-ever Copperbelt Motor Show, following the success of the Lusaka Motor Show, an event that has been running for the past 11 years. The most recent Lusaka Motor Show took place at East Park Mall Piazza in November 2022, attracting over 60 brands. Beginning this year, the organizers […]

By NATION REPORTER
UNITED States Vice President Kamala Harris is welcome but should know that Zambia shall not be a pawn in the supremacy fights the US has with China and Russia, Bowman Lusambo has said.
Mr Lusambo, the former Lusaka Province Minister says Zambia shall at all times protect her sovereign interests as a nation and as a people.
Mr Lusambo said propagating same sex relationships under the guise of human rights promotion was against Zambia’s Constitution, norms and values and that the US Vice-President should be reminded when she arrives today.
“Vice President Harris must be reminded that same sex relationships might be accepted in the US but in Zambia, such acts will never be allowed. As dynamic as culture can be, there are some boundaries that cannot be crossed. We have accepted a lot of American influences such as language, fashion, music and democracy over the years but we will never adopt same sex relationships. We wish to ask her to accept our position the same way the US has been forced to accept the recent decision by the Ugandan Parliament over same sex relations,” Mr Lusambo said.
Mr Lusambo said he wanted to raise a few concerns over the new tide that Washington-Lusaka relations were taking under President Hakainde Hichilema because according to him, it was clear to see that Zambia was on a crusade to over-please the West at the expense of other nations.
“Zambia now finds itself in a very precarious position in the geopolitical landscape which has now affected relations with other countries and the all-important debt restructuring programme,” Mr Lusambo said.
its Lusaka, we wish to remind her and her host President Hichilema that Zambia shall at all times maintain its non-aligned position on key global issues. Since 1964, we have ostensibly implemented this policy position and has served the country well,” Mr Lusambo said.

The synthesis of LSD and psilocybin in the early to mid-20th century sparked not only a new counterculture in the United States but also a new interest in brain science, specifically the role of neurotransmitters. Despite these discoveries, research on psychedelics went dormant for decades due to anti-drug sentiment. A recent renaissance in psychedelic research seeks to understand how these drugs might be leveraged as tools in treating mental illness. While this work has focused largely on mathematical modeling and resting-state neuroimaging, that is now shifting: Cognitive neuroscientists are bringing new rigor to the field, using behavioral and clinical studies to investigate the cognitive effects of psychedelic drugs.