Report proposes a new definition of chronic obstructive pulmonary disease

Despite COPD’s pervasiveness, it is generally assumed that the main instigator in its development is tobacco smoking. The 2023 Global Initiative for Chronic Obstructive Lung Disease or GOLD report is proposing a new definition of COPD, one that acknowledges the key pathogenic role of tobacco smoking but accounts for other factors that also contribute to COPD. The report is now available online in the American Journal of Respiratory and Critical Care Medicine.

Video: Who should be screened for colorectal cancer?

Colorectal cancer is the second-leading cause of cancer death in the U.S. The U.S. Preventive Services Task Force and the Multi-Society Task Force on colon cancer encourage patients to start screening at age 50 unless they have other risk factors like family history or inflammatory diseases that could predispose them to colon cancer. However, African Americans may consider getting screened at an earlier age. Dr. John Kisiel, a Mayo Clinic gastroenterologist, explains who is at risk.

‘Semantic similarity’ leads to novel drug candidates for Parkinson’s disease

The words that researchers use to describe their results can be harnessed to discover potential new treatments for Parkinson’s disease, according to a new study publishing March 2nd in the open access journal PLoS Biology by Angus McQuibban of the University of Toronto, Canada, and colleagues. The study employed an artificial intelligence (AI) system to identify an existing anti-cholesterol drug that has the ability to promote disposal of mitochondria, energy-making components of the cell which are damaged in the disease.

Genetic variants influencing human fertility identified by new research

How many children an individual may have is influenced by reproductive biology and human behavior, according to the largest study to date, which identifies genetic determinants. The study, led by researchers at the Universities of Cambridge, Oxford and Pennsylvania, also identified that the human genome has been influenced by natural selection for thousands of years and continues to affect fertility today.