Bile acids and gut microbes could potentially treat multiple sclerosis, according to new research in mice

Multiple sclerosis is characterized by an immune system gone haywire. A patient’s immune system starts treating the protective coating of the nerves—called myelin—as dangerous. The subsequent nerve damage can cause a variety of symptoms, including muscle weakness, pain and vision loss. MS currently has no cure, and doctors still don’t completely understand what causes it.

How to generate new neurons in the brain

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them.