Inhibition of an enzyme that promotes inflammation may reduce cardiovascular risk in obese people

A research team led by Dr. Martin Mollenhauer from the Heart Center at University Hospital Cologne has investigated the link between obesity and the risk of cardiovascular disease in greater detail. The researchers have discovered that in obese patients and in mouse models, increased levels of the oxidative enzyme myeloperoxidase (MPO) are associated with poorer vascular function.

Sex-specific brain changes reveal how early stress builds resilience in female mice

Early life stress (ELS) can have surprising benefits for female mice, leading to improved emotional regulation and cognitive function. A new study identifies a critical protein, FKBP51, as playing a key role in this adaptive process. The uncovering of sex-specific mechanisms through which ELS can build resilience helps researchers to understand the development of psychiatric disorders and identify potential therapeutic targets.

Rigid grant funding undermines community health centers’ ability to serve vulnerable New Yorkers

Community health centers (CHCs), a cornerstone of New York City’s health care safety net, are being hamstrung by inflexible grant funding structures that limit their ability to provide comprehensive, equitable care, according to a new study by Columbia University Mailman School of Public Health researchers published in BMC Health Services Research.