Endocrine resistance—a major cause of breast cancer deaths—can be underpinned by an epigenetic change called DNA methylation, researchers at the Garvan Institute of Medical Research have discovered. The team successfully reversed this methylation to reduce cancer growth in patient-derived animal models.
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder. β-amyloid (Aβ) deposition in the brain is a crucial contributor to the pathogenesis of AD, mitigating excessive cerebral Aβ burden has been considered as a possible therapeutic strategy for AD.
For the first time, a research team at The Hospital for Sick Children (SickKids) has uncovered a way to potentially reduce the amount of toxic cellular waste accumulating in patients with Zellweger Spectrum Disorder (ZSD).
Nitrous oxide is readily accessible to those who want to use it recreationally for the high it can provide. With just a few clicks, it can easily be bought online. But despite its availability, using the drug—commonly referred to as “whippets” (or “whippits”), “laughing gas,” or “hippie crack”—can have sobering consequences, including permanent, full, or partial paralysis.
Myocardial infarction (MI) is a deadly disease. It can cause serious myocardial ischemic necrosis due to coronary occlusion. The most effective treatment for MI in clinic is reperfusion, e.g., interventional or thrombolytic therapy. However, reperfusion itself could induce more severe injury, called myocardial ischemia/reperfusion injury (MI/RI).
In a study published online in Cell Reports researchers create a zebrafish model for in vivo labeling of brain pericytes, and systematically explored the developmental dynamics of brain pericytes during the early embryonic stage.
Brown fat cells convert energy into heat—a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Area “Life & Health” at the University of Bonn have now identified the protein EPAC1 as a new pharmacological target to increase brown fat mass and activity.
IN Zambia, the specter of prison congestion looms large, with recent statistics revealing an alarming disparity between the inmate population and the holding capacity of correctional facilities. As of January 8, 2024, the Zambia Correctional Service (ZCS) reported a prison population of 25,372, far exceeding the designed capacity of 10,650.
This is exclusive material. To read full story, click on register and choose one of the premium subscriptions to view this content. Login if you are already a premium user.
For centuries, a prevailing theory in philosophy has asserted that at birth the human mind is a blank slate. More recently, the same notion has also held sway in the field of neurobiology, where it is commonly held that neural connections are slowly created from scratch with the accumulation of sensory information and experience.
Sex hormones may contribute to increased anesthetic resistance in women compared with men, according to a new study published in Proceedings of the National Academy of Sciences. General anesthetics exert their hypnotic effects partly by modulating the activity of hypothalamic circuits, which regulate sleep and wakefulness.