Potent and highly selective CDK9 inhibitor for treatment of hematologic malignancies

To evade cell cycle controls, malignant cells rely upon rapid expression of select proteins to mitigate pro-apoptotic signals resulting from damage caused by both cancer treatments and unchecked over-proliferation. Cyclin-dependent kinase 9 (CDK9)-dependent signaling induces transcription of downstream oncogenes promoting tumor growth, especially in hyperproliferative “oncogene-addicted” cancers, such as human hematological malignancies (HHMs).

Breast cancer cells’ self-sacrificial behavior uncovered as potential cause of relapse

For patients with early-stage breast cancer, there is a 7% to 11% chance of relapse within five years after receiving initial treatment, and this rate can be higher for patients with more advanced stages of the cancer. While chemotherapy aims to eliminate all cancer cells, some of them may evade treatment and survive, resulting in the recurrence of the cancer.

It’s been two years of suffering for Zambians – Musenge

By ROGERS KALERO

THE UPND government has in the last two years in government done nothing, apart from going on rampage looting public resources and amassing wealth for themselves in the midst of worsening hunger and poverty in communities and townships, Mwenya Musenge has said

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