From resistance to resilience: Reprogramming drug resistance signals with an artificial gene circuit device

In clinical practice, drug resistance poses a significant challenge in cancer treatment. The process of developing resistance is regulated by complex decision-making pathways and genetic signal networks. The cross-redundancy and compensatory mechanisms between different pathways limit the effectiveness of interventions against drug resistance.

Microparticles from the placenta may offer major clues on the in utero development of neurobehavioral disorders

For 30 years, Cheryl Rosenfeld has studied how biological information gets transferred from mothers to babies during pregnancy. The research is personal for Rosenfeld, whose niece, Sara, was exposed to sedative drugs in utero. Although the little girl was born healthy, she started developing respiratory, neurological, and other health issues in her teenage years.