Key signaling protein identified as possible target for new therapies in hard-to-treat cancers

The unique signaling protein known as TRPM7 can stimulate and interact with an important cellular signaling hub called the AKT machinery, which is a well-known component of multiple cellular functions that drive growth and proliferation. This interaction causes a significant increase in the gene expression of COX-2, an important pro-inflammatory and pro-tumorigenic gene that is highly expressed in cancer cells and typically coincides with poor prognosis.

Estimating gastric cancer risk using DNA methylation and lifestyle data

Gastric cancer is the fourth leading cause of cancer-related mortalities worldwide. Various environmental and lifestyle-related factors, like tobacco and alcohol consumption, are known to contribute to the risk of gastric cancer. Further, infection by Helicobacter pylori–a bacterium found in the stomach–is another leading risk factor for the onset of the disease.