Better cancer diagnosis thanks to digital 3D images

It all started with an innocuous question at the start of Francesca Catto’s doctoral thesis: Wouldn’t it be nice if tissue samples could be colored and digitally displayed as a 3D image? For more than 100 years, histology, a branch of pathology that deals with tissue changes, has been using an analog method that involves cutting tissue samples into micrometer-thin slices (about 7 times thinner than a human hair) and examining them for pathological mutations under the microscope. This technique results in 1 in 6 people being misdiagnosed and cancer cells going undetected.

Uncovering the role of skin microbiome and immune response in cutaneous leishmaniasis

The parasitic disease leishmaniasis is found primarily in Central and South America, the Mediterranean region, the Middle East, and Central Asia and is transmitted to humans by a sand fly. An estimated 1.5 million new cases of cutaneous leishmaniasis—the most common form of the disease—occur each year. There is no vaccine, and treatment with anti-parasitic drugs is often unsuccessful.

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THE Patriotic Front is in danger of being devoured into oblivion by its own members as the battle to elect a new president takes a vicious twist.

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Researchers identify ‘switch’ to activate cancer cell death

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die. This new ability to trigger programmed cell death could open the door for improved cancer treatments. The findings were published Oct. 14 in the journal Cell Death & Differentiation.

We can’t defeat cancer without acknowledging the differences between men and women, say scientists

For generations, the medical community has used the “standard human”—a 70-kilogram male—to guide education, research and practice. This means that for many conditions, although the recommended type, dosage and duration of treatment may be effective for the group of males who happen to weigh close to 70 kg, they might be far from optimal for most of the population, including all females.