A new study from Nagoya University has unraveled a crucial link between how cancer cells cope with replication stress and the role of Taurine Upregulated Gene 1 (TUG1). By targeting TUG1 with a drug, the researchers were able to control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors such as glioblastomas.
How antibodies offer protection against an infection with HIV
A team of researchers investigating the transmission of HIV have discovered that HIV antibodies provide sterilizing immunity by inhibiting the infection of the first cell. The research is published in the journal Cell Reports Medicine.
Monkey survives for two years with genetically engineered pig kidney
A large team of medical researchers affiliated with multiple institutions in the U.S. reports that genetically altering the genome of pigs can reduce the chance of rejection of their organs when transplanted into a primate.
Traumatic memories can rewire the brain: Study
Scientists have long speculated about the physical changes that occur in the brain when a new memory is formed. Now, research from the National Institute for Physiological Sciences (NIPS) has shed light on this intriguing neurological mystery.
Study identifies potential putative drug compounds for treating interstitial lung disease
A research team has identified a potential new drug for interstitial lung disease, a condition affecting approximately 4.7 million people worldwide, and validated its protective effects using patient-specific induced pluripotent stem cell-derived lung organoids. The collaborative effort was led by Professors Masatoshi Hagiwara (Graduate School of Medicine, Kyoto University) and Shimpei Gotoh (Department of Clinical Application), and their findings are published in the journal iScience.
Kapala ordered to issue statement on exclusion of local fuel transporters
By NATION REPORTER
FIRST deputy Speaker Malungo Chisangano has directed Minister of Energy Peter Kapala to explain to Parliament on Thursday, next week on reports that local transporters were excluded in the transportation of fuel.
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Study finds we can respond to verbal stimuli while sleeping
Sleep is not a state in which we are completely isolated from our environment: while we sleep, we are capable of hearing and understanding words. These observations, the result of close collaboration between teams at Paris Brain Institute and the Sleep Pathology Department at Pitié-Salpêtrière University Hospital in Paris, call into question the very definition of sleep and the clinical criteria that make it possible to distinguish between its different stages.
Big blood savings: Large trial shows taking less blood for lab testing reduces transfusions in intensive care
A world-first clinical trial published in JAMA could provide an easy way to save tens of thousands of units of blood every year in Canada and much more worldwide.
Study reveals brain connectivity patterns can predict suicide risk in patients with late-life depression
Suicidal ideation, plans and behaviors are serious health threats among older adults with late-life depression, resulting in a higher likelihood of death than in any other age group. The increasing prevalence of depression in late life speaks for the urgent need for cost-effective, objective screening of suicide risk.
Win–win in muscle research: Faster results and fewer laboratory animals thanks to new method
To study muscle diseases, scientists rely on the mouse as a model organism. Researchers at the University of Basel have now developed a new method that is not only faster and more efficient than conventional ones but also greatly reduces the number of experimental animals needed for studying the function of genes in muscle fibers.