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The U.S. Food and Drug Administration (FDA) recently approved palovarotene (Sohonos) as the first treatment for fibrodysplasia ossifcans progressiva (FOP), a severely disabling condition that causes abnormal bone formation in place of soft and connective tissues. The approval was based on research conducted through a multicenter clinical trial, including patients being treated with the drug at UC San Francisco’s Metabolic Bone Clinic.

Getting enough sleep has never been more difficult in today’s fast-paced environment. Yet new research from investigators in the Channing Division of Network Medicine of Brigham and Women’s Hospital, a founding member of the Mass General Brigham health care system, highlights why getting a good night’s sleep is critical to staying healthy.

Fatty liver disease is exploding globally, affecting as many as 30% of people in Western countries. Apart from alcohol, obesity and diabetes are among the most dominant risk factors.

By MILLENNIUM REPORTER

SOUTHERN Africa Network against Corruption executive director Gregory Chifire says the fight against money laundering corruption and other illicit financial activities should continuously align itself to modern trends. 

Researchers from Karolinska Institutet have published a study in Alzheimer’s Research & Therapy that addresses possible associations between chronic stress, mild cognitive impairment and Alzheimer’s disease. The study shows how people aged between 18 and 65 with a previous diagnosis of chronic stress and depression were more likely than other people to be diagnosed with mild cognitive impairment or Alzheimer’s disease.

A new systematic review by researchers at UCL and Wingate University has highlighted the importance of identifying childhood verbal abuse by adults as a standalone subtype of child maltreatment, to ensure targeted prevention and address the lasting harm it can inflict.

A team of researchers at the Medical University of Vienna has discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein called P-glycoprotein (P-gp). This discovery opens up new possibilities for delaying relapse and is particularly relevant for aggressive triple-negative breast cancer (TNBC), for which there are currently few effective treatments.

Rapid identification of patients contaminated by “superbacteria” known as “carbapenem-resistant Enterobacteriaceae” (CRE), with early isolation of these patients, reduces transmission in hospital emergency departments. However, keeping them in the emergency room (ER) for more than two days undermines containment because it increases the risk of infection via colonization.

MDMA, commonly known as ecstasy, is a recreational psychedelic drug often used at parties and dance clubs because it creates feelings of closeness and social connection with others. Because of this “empathogenic” effect, researchers are also interested in its potential use as a complement to traditional talk therapy. In fact, two recent successful clinical trials support the use of MDMA-assisted therapy as a treatment for post-traumatic stress disorder (PTSD).

A novel liquid biopsy test may help determine which patients with non-small cell lung cancer that has spread beyond the lungs are most likely to benefit from targeted, high-dose radiation, rather than drug-based therapy, a new study suggests. Findings were presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting and published in npj Precision Oncology.