Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results, published in Nature, could help pinpoint treatment-resistant tumors.
Researchers from Auburn University, in a landmark collaboration with Brazil’s Oswaldo Cruz Foundation (FIOCRUZ), the world’s leading research institution on Chagas Disease, have published a significant study in the journal Biochemistry. The study sheds new light on how the Chagas Disease parasite invades human cells—a crucial step towards developing effective treatments for this neglected tropical disease.
Even preschool children can recognize a hypocrite. And, just like adults, they don’t have the best opinion of such people: they assess hypocrites more negatively than they do other people who break commonly accepted rules, a study conducted by researchers from SWPS University shows.
Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by its accumulation of a large number of mutations. Although some of these alterations should be recognized as a threat by our defenses, melanomas often escape immune system surveillance. As a result, more than half of patients do not generally respond to current immunotherapies. Understanding and avoiding this phenomenon is one of the greatest challenges in oncology today.
A team of Norwegian researchers, through international collaboration, found that the use of artificial intelligence (AI) during colonoscopy increased the detection of polyps by about 8%, but the risk of cancer was minimally affected.
Steroid hormone levels in healthy adults are influenced by oral contraceptives and smoking, as well as other lifestyle choices and factors such as biological sex and age, according to new research that has just been published in the journal Science Advances.
Exercise could potentially reduce the recurrence rate of breast cancer, new research from Edith Cowan University (ECU) has found.
As a measles outbreak spreads across the U.S., doctors are now seeing a new and unexpected danger: children getting sick from taking too much vitamin A.
Triglycerides are a vital source of energy, but when levels become dangerously high, they can lead to serious health complications, including pancreatitis. One such condition, chylomicronemia, is a rare but severe disorder in which triglyceride levels exceed 1,000 mg/dL, increasing the risk of life-threatening complications.
Measles is a highly contagious disease that was declared eliminated from the U.S. by the World Health Organization 25 years ago due to the success of vaccination efforts. Yet, Texas counties primarily in the South Plains and Panhandle regions, continue to deal with the state’s largest measles outbreak in 30 years.