Successful CAR-T cell therapy for end-stage multiple myeloma using advanced cellular product performed in Hong Kong

A clinical team has spearheaded the use of CAR-T cell therapy for blood cancers. The researchers recently treated the first myeloma patient with this therapy, resulting in a very good response without severe complications. The expansion of this innovative treatment to myeloma patients offers new hope for those who have not responded to traditional treatment, marking a significant milestone in advancing health care in Hong Kong.

Compelling data points to a single, unknown respiratory virus as cause of Kawasaki disease

Research from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago strongly suggests that Kawasaki disease is caused by a single respiratory virus that is yet to be identified. Findings contradict the theory that many different pathogens or toxins could cause this disease that can lead to serious cardiac complications in young children.

Gene editing with adeno-associated virus vector offers hope for hereditary deafness

An R75W mutation in the gap junction β2 (GJB2) gene causes severe fragmentation of gap junction plaques, connecting adjacent cells and leading to syndromic hearing loss. In a new experimental study, scientists from Juntendo University in collaboration with researchers from the University of Tokyo have developed an adeno-associated virus (AAV) vector-mediated genome editing approach to repair the R75W mutation.