Cancer-infecting virus ‘warms up’ cold tumors and improves immunotherapy

Equipping cancer-infecting (oncolytic) viruses with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy to shrink or completely clear aggressive tumors in mice, according to a new study in the Journal of Experimental Medicine led by University of Pittsburgh and UPMC researchers. The results pave the way for clinical trials combining oncolytic viruses with immunotherapy.

Researchers propose a new way to evaluate the impact of medical research

Scientific journals and research papers are evaluated by a metric known as their “impact factor,” which is based on how many times a given paper is cited by other papers. However, a new study from MIT and other institutions suggests that this measure does not accurately capture the impact of medical papers on health outcomes for all patients, particularly those in low- or middle-income countries.

Researchers uncover mysteries behind immune response to hemophilia A treatment

Patients with the genetic disorder hemophilia A receive factor VIII protein replacement treatments to replenish this clotting protein in their blood, thus preventing dangerous bleeding. Unfortunately, about 30% of these patients develop antibodies against the treatment and until now, despite more than 80 years of clinical experience with this complication, little has been known about its mechanism.

Traditional ceremonies a fountain of Zambia’s heritage – Sikumba

 

By NATION REPORTER

TRADITIONAL ceremonies are not only a fountain of Zambia’s cultural values and heritage but have also become a tourist attraction for both local and international tourists, Rodney Sikumba has said.

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