Protein inhibits development of COVID-19 in live animals

A mammalian protein previously shown by UT Southwestern microbiologists to inhibit the virus that causes COVID-19 in cell culture also protected live mouse models, significantly limiting infection in the lung cells and diminishing the symptoms. The findings, published in Nature Microbiology, could lead to new strategies to treat COVID-19, which still infects thousands and kills hundreds in the U.S. every week.

Giving patients anti-platelet medication sooner after stroke treatment may significantly improve patient recovery

Administering anti-platelet medication within 24 hours of mechanical thrombectomy, an effective procedure for stroke, may help patients more successfully recover and prevent high-risk individuals from experiencing additional strokes, according to a study presented today at the Society of NeuroInterventional Surgery’s (SNIS) 20th Annual Meeting.

Cardiac reparative and immune regulatory role of hPSC-derived epicardial cells uncovered for infarcted hearts

Recently, research groups led by Prof. Yang Huangtian from Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences (CAS) and collaborator Prof. Gao Ling from Shanghai East Hospital of Tongji University found that intramyocardial injection of human embryonic stem cell-derived epicardial cells (hEPs) at the acute phase of myocardial infarction (MI) ameliorates functional worsening and scar formation in mouse and swine hearts.

High-salt diet in rats slows metabolism and energy production of kidneys

Some parts of the metabolic pathway (the process of turning food into energy) slow in response to a high-salt diet, even as the kidneys produce and use more energy when exposed to high salt intake. The surprising finding is documented in a new research study by first author Satoshi Shimada, Ph.D., in the journal Function. Shimada and other researchers from the Medical College of Wisconsin and Jackson Laboratory in Bar Harbor, Maine, noted this result is similar to what happens in malignant tumors.

Researchers report on a low-cost potential therapy for spinal cord injuries

A spinal cord injury is a life-altering event, and the effects, such as muscle weakness and paralysis, can dramatically disrupt a person’s life. While there is no cure for paralysis, there has been some progress in developing potential treatment options to improve symptoms. Still, much of it remains out of reach to many patients. A person with a complete spinal cord injury may benefit from a spinal cord stimulator, but cost, safety and patient willingness to undergo surgery are among the barriers to treatment.