Formulate positive discrimination tax system for SMEs, gov’t urged

By BUUMBA CHIMBULU
GOVERNMENT should not apply tax systems suitable for large corporate entities and apply them to small-scale and medium-scale enterprises as this will encourage tax evasion.

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Translational PET tracer visualizes brain cholesterol metabolism

A new PET radiotracer that visualizes the enzyme primarily responsible for metabolic cholesterol degradation in the brain has been successfully validated, according to research presented at the 2023 Society of Nuclear Medicine and Molecular Imaging Annual Meeting. Known as 18F-Cholestify, the radiotracer holds the potential to substantially improve clinical neuroimaging, laying the foundation for new image-guided trials to study neurodegenerative diseases and neurological disorders.

New tool to help harness human pangenome diversity for clinical interpretation of variants

Researchers from GeneDx have published a paper titled “Multiscale analysis of pangenomes enables improved representation of genomic diversity for repetitive and clinically relevant genes” in Nature Methods. The work details research in which the researchers developed a new computational tool, the PanGenome Research-Tool Kit (PGR-TK), for scalable analysis of clinically relevant genes that were previously too complex to analyze.

Intermittent fasting and traditional calorie counting shown to be about equal for weight loss

A small randomized controlled trial found that time-restricted eating, also known as intermittent fasting, produced similar weight loss results to traditional calorie counting in a racially diverse population of adults with obesity. The study also showed that participants who engaged in 8-hour time restricted eating had improved insulin sensitivity compared to those in the control group who ate their calories any time over 10 or more hours a day. The study is published in Annals of Internal Medicine.

Research team uses genomic testing broadly for rare diseases, improves patient care

A Mayo Clinic study published in Journal of Translational Medicine has evaluated the use of genomic testing broadly for rare diseases. With the increased use of genomic testing such as multi-gene panels, exome sequencing and genome sequencing in the past decade, there is a greater opportunity to better diagnose and treat patients with rare diseases. According to the National Institutes of Health, as many as 10,000 distinct rare diseases exist and an estimated 25-30 million Americans are affected by one of them.