IMF benchmarks not met – Mmembe 

Socialist Party leader Fred M’membe says it is mischievous for government to claim that all benchmarks set by the International Monetary Fund (IMF) have been met when it is clear that Zambia may not access the second tranche of US$188 million.

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Change in breast density over time linked to cancer risk

Many middle-aged and older women get mammograms every one to two years to screen for breast cancer, as recommended by their doctors. A study by researchers at Washington University School of Medicine in St. Louis indicates that previous mammograms hold underutilized data that could help identify women at high risk of breast cancer and even reveal which breast is likely to be affected.

Dual-action antibiotic found that kills C. difficile, preventing reinfections

A team of biochemists at the University of Notre Dame has found a possible new way to treat patients infected with Clostridioides difficile, a type of bacteria that causes serious gastrointestinal problems. In their study, reported in Proceedings of the National Academy of Sciences, the group searched medical databases for antibacterial molecules that might work better for patients with C. difficile infections.

Analytical methods for preclinical stage gene therapy programs

Using a process confirmation vector, researchers developed and optimized a size exclusion chromatography (SEC) with UV and multi-angle light scattering (MALS) method to measure the level of empty capsids during manufacturing. In a new study, the researchers showed that SEC-MALS outperformed other analytical methods and correlated well with sedimentation velocity analytical ultracentrifugation (SV-AUC) values of full-to-empty particles. The study is published in the peer-reviewed journal Human Gene Therapy.

Tuberculosis disease intensifies HIV antibody response in people with HIV

New research from Boston Medical Center found that people living with HIV that have had pulmonary tuberculosis had broader and more potent HIV antibody responses and differences in HIV sequences predicted to be antibody resistant as compared to those without suspected or documented tuberculosis. Published in iScience, the study suggests that concomitant tuberculosis disease has a significant impact on HIV immune responses and the viruses circulating in people living with HIV.