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In a first, a team from Brigham and Women’s Hospital and Boston Children’s Hospital successfully treated an aggressive vascular malformation in an infant’s brain before birth, avoiding potentially fatal symptoms after delivery.

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it. While the gene was discovered more than four decades ago, researchers have so far been unsuccessful at determining exactly how it works. Now, in a recent study published in Cancer Discovery, researchers at The Wistar Institute have uncovered a key mechanism as to how p53 suppresses tumors.

The value of unpaid care in England and Wales is now estimated to be £162 billion, exceeding that of the entire NHS budget in England for health service spending, which by comparison was £156 billion for 2020–21.

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disorder that progresses slowly and is characterized by cough, asthma, dyspnea and shortness of breath. Previous studies have shown that cigarette smoke (CS) is one of the major causes of COPD. Chronic bronchial inflammation induced by CS promotes lung injury, fibrosis and remodeling, finally leading to emphysema, a lung condition that causes shortness of breath. However, the potential mechanism of CS-mediated COPD symptoms remains incompletely understood.

Scientists at the University of Liverpool have figured out how mutations in a gene called FBXL4 can lead to an excess of mitophagy—the disposal of mitochondria, the ‘power stations’ within nearly all human cells.

Diabetes is a known risk factor for developing cancer, but could it also predict how cancer patients respond to treatment?

Summer Oriyavong first heard the ringing bells and tapping sounds in her head when she was in middle school. Whispering voices and shadowy visions, ones that made her feel superior and special, soon followed.

Common food additives known as metal oxide nanoparticles may have negative effects on your gut health, according to new research from Binghamton University, State University of New York and Cornell University.

Researchers at Karolinska Institutet and Karolinska University Hospital have together with health economists at Linköping University analyzed costs for various methods to diagnose genetic causes of intellectual disability. The study, published in Scientific Reports, shows that the costs when using whole genome sequencing as a first-line diagnostic test were lower compared to chromosomal microarray analysis.

Recently, a research group from Hefei Institutes of Physical Science (HFIPS) of Chinese Academy of Sciences (CAS) and The Second Hospital of Anhui Medical University dissected, for the first time, the somatic mutation profile of familial colorectal cancer with the coinheritance of mutations in both APC and MLH1 genes.