Small proteins in the heart play big role

A heartbeat is a carefully coordinated series of electrical signals led by sodium ion channels, which tell the heart when to contract and to relax. Any disruption to these signals may lead to cardiac diseases such as an irregular heartbeat, or arrhythmia. Two researchers at Washington University in St. Louis have taken a closer look at this process at the molecular level and have found what may provide new insights into different heart conditions and how to develop better therapies.

Self-reported functional impairments, frailty associated with higher health care costs in Medicare beneficiaries

A study of more than 8,000 comprehensively characterized Medicare beneficiaries has found that the addition of self-reported functional impairments and physical frailty to claims-based measures of multi-morbidity and frailty identifies large differences in spending attributable to impairments and frailty. The findings are published in Annals of Internal Medicine.

Keeping COVID-19 in check will likely require periodic boosters

Between natural infection and a global vaccination campaign, most people now have some immunity against the virus that causes COVID-19. This widespread immunity hasn’t stopped people from getting infected, but it has dampened the massive waves of illness and death that roiled the globe in the early years of the pandemic. Keeping the virus in check requires maintaining this level of immunity, a difficult task because the virus is constantly spinning off new variants that can partially evade antibodies elicited by vaccines and prior infections.