Genome analysis just got personal

Life on Earth comes in a beautiful assortment of different shapes, sizes and colors, thanks to genetic mutations. Some mutations are beneficial, some are perilous, and some don’t do much of anything. Every person has around 4.5 million genetic variations. But are those variants helpful or hurtful? Geneticists have been trying to find the answer for half a century. Their biggest obstacle nowadays? Standard human genome sequence reference data.

A bright spot in the treatment of lateral disk meniscus injuries for youth

Tearing their meniscus—a crescent-shaped piece of a soft cushion of cartilage located between the femur and tibia—can be devastating for young athletes. It is easily damaged in people with congenital lateral discoid meniscus or those that are physically active and once damaged, the meniscus cannot repair itself. The most common method has been to remove the damaged portion of the meniscus, but in recent years meniscus-sparing surgeries, that suture the margins of the meniscus at the tear, have begun to spread.

The role of lipids in blood cancer: New insights into uncharted territory

Cells contain diverse populations of molecules called lipids, which are organic fatty compounds. Lipid metabolism, the synthesis and breakdown of these lipids, plays a key role in regulating the composition and functions of cells and cell membranes. An enzyme known as ELOVL6 elongates chains of fatty acids and is important in several cellular metabolic processes. However, the relationship between lipid metabolism and blood development and disorders is an area of research with minimal activity so far.