Targeting type of B cell could reduce lupus disease, study suggests

A group of University of Pittsburgh researchers has given new meaning to “knowing your ABCs.” In a new study, published in the Journal of Experimental Medicine, the team showed that a type of immune cell called age-associated B cells, or ABCs, are important drivers of lupus and that targeting these cells in a mouse model reduced disease, pointing the way to new therapies.

Heart-healthy lifestyle linked to a longer life, free of chronic health conditions

Two new studies by related research groups have found that adults who live a heart-healthy lifestyle, as measured by the American Heart Association’s Life’s Essential 8 (LE8) cardiovascular health scoring, tend to live longer lives free of chronic disease. The preliminary studies are being presented at the American Heart Association’s Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Scientific Sessions 2023, held in Boston, February 28-March 3, 2023. The meeting offers the latest science on population-based health and wellness and implications for lifestyle and cardiometabolic health.

Report proposes a new definition of chronic obstructive pulmonary disease

Despite COPD’s pervasiveness, it is generally assumed that the main instigator in its development is tobacco smoking. The 2023 Global Initiative for Chronic Obstructive Lung Disease or GOLD report is proposing a new definition of COPD, one that acknowledges the key pathogenic role of tobacco smoking but accounts for other factors that also contribute to COPD. The report is now available online in the American Journal of Respiratory and Critical Care Medicine.