Gut microbiome can play key role in response to CAR-T cell cancer immunotherapy

Scientists from German Cancer Research Center (DKFZ), together with colleagues from Germany, Israel, and the U.S., have found that the gut microbiome may modulate the efficacy of CAR-T cellular immunotherapy CAR-T cells in patients with B cell lymphomas. Individualized microbiome information retrieved from patients’ gut microbiomes prior to initiation of CAR T therapy could accurately predict their subsequent responsiveness to therapy, but only in the condition that these patients were not pre-treated with broad spectrum antibiotics.

Racial health inequality in prostate cancer associated with facility-level disparities

Racial minorities in the United States are less likely to receive treatment for prostate cancer and, overall, have worse survival outcomes compared to individuals who are white. Typically, patient-level and physician-level factors have been used to explain the racial and socioeconomic differences in prostate cancer disparities. However, a new study led by investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, investigated the role of facilities themselves in relation to these disparities. Their results are published in Urologic Oncology: Seminars and Original Investigations.

Child and teen mortality in the US experiences largest increase in decades

Child and adolescent mortality rates in the United States rose by 20% between 2019 and 2021, the largest increase in at least 50 years, according to an editorial published Monday in the Journal of the American Medical Association. These increases follow decades of progress in lowering the rate of death from childhood diseases. The alarming spike in pediatric mortality is primarily due to deaths from homicide, accidental drug overdoses, motor vehicle accidents and suicide among those ages 10 to 19.

Public health insurance for parents improves children’s reading skills, study finds

A recent series of three papers authored by Caitlin Lombardi demonstrate the effects of publicly funded health insurance for parents on three different metrics of children’s health and development. The newest, published in Southern Economic Journal, highlights a significant boost to children’s reading scores when their parents gain healthcare coverage.

Epilepsy could become easier to pinpoint with blood test

Researchers from Lund University in Sweden have discovered higher levels of immune proteins in the blood before and after an epileptic seizure. The possible biomarkers can be identified using a simple blood test. Diagnosing epilepsy is currently resource intensive, and distinguishing it from other conditions can be challenging. Better diagnostic methods as soon as the patient seeks medical care after a suspected seizure are therefore an urgent necessity.