Explaining why some patients may test positive for COVID-19 long after recovery

SARS-CoV-2, the virus that causes COVID-19, seems to have become a permanent presence in our lives. Research from Whitehead Institute Founding Member Rudolf Jaenisch’s lab reveals that this may be true on multiple levels. Jaenisch, postdoc Liguo Zhang, and colleagues have shown that when the virus infects people, it is capable of integrating parts of its genetic code into the human genome through a process called reverse transcription. This genomic integration is rare, but due to how many hundreds of millions of people have been infected, it has likely occurred many times.

Injectable tissue provides significant, long-term relief for chronic back pain, finds research

A minimally invasive treatment that injects allograft disk tissue into the spine to relieve pain associated with degenerative disk disease provides significant improvement in pain and function over a sustained period, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Phoenix, March 4–9.

Study reinforces potential use of zika virus to combat prostate cancer but points to possible side-effect

Preclinical trials have shown that zika virus can inhibit the spread of prostate cancer, suggesting its potential use in treating the disease. However, a new study by researchers at the State University of Campinas (UNICAMP) in São Paulo State, Brazil, shows that zika can trigger a persistent inflammatory process in healthy epithelial cells and damage the male reproductive system.

How gut bacteria can impact treatments for cancer

A large team of cancer researchers affiliated with multiple institutions in Germany, working with a colleague from the U.S., has discovered some of the ways gut bacteria can positively impact treatments for cancer. In their study, published in the journal Nature, the group studied the impact of gut microbiota on chemotherapy given to patients with pancreatic ductal adenocarcinoma. Le Li and Florencia McAllister with the University of Texas MD Anderson Cancer Center, have published a News and Views piece in the same journal issue, outlining the work done by the team in Germany.