Genetic adaptations help Amazonian populations resist Chagas infection

Chagas disease affects approximately 6 million people only in Latin America and is one of the leading causes of death in this region. This infectious disease, also called American trypanosomiasis, is caused by the parasite Trypanosoma cruzi (T. cruzi). However, despite being in contact with the parasite, Amazonian populations hardly suffer from Chagas infection. A new study aimed to find out why.

A safer method of generating pancreatic islet-like cells from human iPS cells

Junior Associate Professor Taro Toyoda and his research group, in collaboration with industrial companies including Orizuru Therapeutics, Inc., conducted a safety assessment of the differentiation inducers used in the preparation of human iPSC-derived pancreatic islet cells (iPIC) from human iPS cells and developed a safer differentiation protocol for generating iPICs based on those new findings. The research results were published in Stem Cell Research & Therapy on January 5, 2023.