The hormone glucose-dependent insulinotropic polypeptide (GIP) is considered obesogenic. In contrast, GIP receptor agonists (GIPRAs) have shown reduced feeding and body weight in an obese mouse model. Therefore, the precise effects exerted by GIP and GIPRAs remain elusive. Recently, researchers demonstrated acute feeding inhibition and lowered body weight in mice with diet-induced obesity treated with GIPFA-085, a long-acting GIPRA. Their findings provide a scientific basis for GIP therapy for diabetes and obesity.