Team successfully generates mouse models for two subtypes of multiple myeloma

B lymphocytes—also known simply as B cells—play a central role in the immune system. If pathogens enter the body, B cells are activated and develop into plasma cells, which then release antibodies. One important step in this process is the germinal center reaction. If the B cells’ maturation into plasma cells is disrupted, multiple myeloma can develop—one of the most common blood cancers. This disease has a variety of subtypes and is not yet curable.