Restoration of immune defense in liver disease

Patients suffering from chronic liver disease don’t respond to vaccination and are at high risk of viral infections. In these patients, virus-specific T-cells are defect and unable to eliminate viral pathogens. A research team led by ImmunoSensation2 member Prof. Zeinab Abdullah at the University Hospital Bonn (UKB), in collaboration with colleagues from the University of Oxford and the Technical University Munich, has now discovered the molecular mechanism underlying the suppression of T-cell immunity.