Feed them or lose them: How developing nerve cells are influenced by essential amino acids

Brain development consists of a sequence of coordinated steps, which are mainly instructed by our genes. During these steps, the proper positioning and functionality of nerve cells in the brain (neurons) are critical—nonfunctional or incorrectly positioned neurons can lead to severe neuropathological consequences. Mutations in genes coordinating this program are often linked to neurodevelopmental disorders; however, environmental stressors such as nutrient scarcity or malnutrition can also influence the development of the brain. Still, very little is known about the importance of specific nutrients and the role of metabolism during brain development.