RNA editing guides immune cells to areas of tissue injury

A team of international scientists led by the Heidelberg University, Medical Faculty Mannheim, and the Newcastle University (Great Britain) has succeeded in decoding a new mechanism of immune cell trafficking by examining vascular diseases. Surprisingly, the fine-tuning of this fundamental immune defense process is carried out by an RNA editing system (ADAR2) in the endothelial cells that line the blood vessels. This knowledge could open up new therapeutic approaches for a large number of inflammatory diseases.

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