Hypothermic neuroprotection by targeted cold autologous blood transfusion in a non-human primate stroke model

Therapeutic hypothermia is a well-established therapy with clear neuroprotective effects. It has been widely used in cases of neonatal hypoxic encephalopathy and cardiac arrest. Researchers have been attempting to apply therapeutic hypothermia to the treatment of acute ischemic stroke for decades. However, many hypothermia induction methods that have proven effective in rodent transient cerebral ischemia models have encountered challenges in clinical translation.