Pancreatic cancer vaccine plus immunotherapy and antibody spark immune system response in pancreatic cancers

Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and urelemab, an anti-CD137 agonist antibody treatment, is safe, increases the amount of cancer-killing immune system T cells in the tumors and appears effective when given two weeks prior to cancer-removal surgery, according to new research directed by Johns Hopkins investigators.

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